Monocytes and impaired leukocyte migration inhibitory factor production in head and neck squamous carcinoma
- 1 January 1988
- journal article
- research article
- Published by Wiley in Head & Neck Surgery
- Vol. 10 (3) , 187-194
- https://doi.org/10.1002/hed.2890100307
Abstract
Impaired cell-mediated immunity has been consistently associated with head and neck squamous carcinoma (HNSC). Previous work has implicated monocytes in this impairment. The present study shows that in a subgroup of untreated patients with advanced HNSC, monocytes are responsible for impaired in vitro lymphokine (leukocyte migration inhibitory factor) production. In view of recent studies suggesting interactions between lymphokines and monocytes in the immune response, the present findings may be relevant to future immunotherapeutic approaches.Keywords
This publication has 22 references indexed in Scilit:
- The ability of macrophages from head and neck cancer patients to kill tumor cells: Effect of prostaglandin inhibitors on cytotoxicityCancer, 1984
- Lymphokine Production and Lymphocyte Subpopulations in Patients With Head and Neck Squamous CarcinomaJAMA Otolaryngology–Head & Neck Surgery, 1984
- Mononuclear phagocyte function in head and neck cancer. Chemotactic responsiveness of blood monocytes in correlation between histologic grade of the tumor and infiltration of these cells into the tumor areaCancer, 1984
- Mononuclear phagocyte function in head and neck cancer: Depression of murine macrophage accumulation by low molecular weight factors derived from head and neck carcinomasThe Laryngoscope, 1984
- The Effect of Indomethacin on the Growth of Epidermoid Carcinoma of the Palate in RatsJAMA Otolaryngology–Head & Neck Surgery, 1983
- Indomethacin sensitive suppressor cell activity in head and neck cancer patients pre- and postirradiation therapyCancer, 1982
- Regression of Head and Neck Carcinoma With a Prostaglandin-Synthesis InhibitorJAMA Otolaryngology–Head & Neck Surgery, 1981
- Deficient cell‐mediated immunity in head and neck cancer patients secondary to autologous suppressive immune cellsThe Laryngoscope, 1978
- Dinitrochlorobenzene Skin Sensitization and Peripheral Lymphocyte Count: Predictors of Survival in Head and Neck CancerAnnals of Otology, Rhinology & Laryngology, 1976
- Effect of phytohaemagglutinin in the leucocyte migration inhibition test as a measure of cell-mediated immunityJournal of Clinical Pathology, 1974