EEG PROFILE AND BEHAVIORAL-CHANGES AFTER A SINGLE DOSE OF CLOZAPINE IN NORMALS AND SCHIZOPHRENICS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 12  (5) , 613-633
Abstract
Clozapine, a powerful neuroleptic with unique clinical efficacy (and without parkinsonic side-effects), apparently has an unusual EEG profile. The EEG changes after clozapine, especially when instrumentally quantified, demonstrated predictive value of EEG. Similarities of the EEG profile of clozapine with the profile of thymoleptic compounds indicated its possible thymoleptic effect. This later was the case with therapeutic studies in human depression. The EEG profile of clozapine in volunteers was similar to the EEG profile in schizophrenics (with appropriately higher doses). Instrumental quantification was performed with spectral and iterative interval analysis to show the advantages of each method and also their complementary value.

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