INTERACTIONS BETWEEN DRUGS AND SALIVA-STIMULATING PARAFILM AND THEIR IMPLICATIONS IN MEASUREMENTS OF SALIVA DRUG LEVELS

  • 1 January 1976
    • journal article
    • letter
    • Vol. 13  (2) , 357-360
Abstract
The interaction between Parafilm and 4 tranquilizers in their neutral phosphate buffer solutions resulted in various degrees of loss of the drugs from the solutions. The values of loss ranged from 15-34% for chlorpromazine and 8-42% for butaperazine at the initial concentration range of 2-20 .mu.g/ml at room temperature (22 .+-. 1.degree. C). Under the same conditions, the values of loss from saliva for these 2 drugs were fairly constant; about 25% and 17%, respectively. For diazepam and chlordiazepoxide, the losses from the buffer solution were below 5%.

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