11?-Hydroxylase with Affinity to C-21-Deoxysteroids from Ovaries of Patients with Polycystic Ovary Syndrome
- 1 December 1975
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 41 (6) , 999-1002
- https://doi.org/10.1210/jcem-41-6-999
Abstract
When ovarian mitochondria from a patient with polycystic ovary syndrome (POS) were incubated with [7-3H]17α-hydroxypregnenolone and [414-C]17α-hydroxyprogesterone, 11β-hydroxylated metabolites were obtained. When the same mitochondrial preparation was incubated with [7-3H]17α-hydroxypregnenolone and [4-14C]11-deoxycortisol no 11β-hydroxylated derivatives of 11-deoxycortisol were found. These results are compatible with and support the conclusion that the ovary of POS patients who excrete pregnanetriolone contains an 11β-hydroxylase capable of hydroxylating C-21-deoxysteroids but not C-21-hydroxysteroids.Keywords
This publication has 0 references indexed in Scilit: