Isolation of a brain peptide identical to the intestinal PHI (peptide HI)
- 21 March 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 153 (2) , 248-252
- https://doi.org/10.1016/0014-5793(83)80617-6
Abstract
The isolation of a brain peptide identical to the intestinal peptide PHI (peptide HI) is described. The peptide was isolated from porcine brain extract using a chemical assay method based on its C‐terminal isoleucine amide structure. The complete amino acid sequence of the peptide was found to be: This sequence is identical to the intestinal peptide thus demonstrating PHI to be a brain‐gut peptide. The role of PHI in the central nervous system as a neurotransmitter or neuromodulator is discussed.Keywords
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