Testicular Cancer: Management of Metastases, with Report of a New Chemotherapeutic Agent

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Abstract
Postorchiectomy abdominal irradiation for testicular cancer has become a well established procedure during the last decade. While this is not a common neoplasm, 99 cases have been seen since 1935 at the Tumor Institute of the Swedish Hospital of Seattle (Table I). Of this number, 22 were untreated. Beside 10 seen in consultation, 6 were moribund, in 3 instances even beyond biopsy, and in general susceptible only to pharmacological palliation. Three were seen with widespread metastases, while 2 others refused treatment on religious grounds. The treated cases fall into two groups: those treated prior to 1946 and those seen subsequently (Table II). In the earlier period the practice was orchiectomy, with irradiation only for recurrences and metastases. The more recent picture is good, as cancer goes. The favorable results recorded by Friedman and Moore (1), Milton Friedman (2), and others (3) have influenced our surgeons, since 1946, to call for intensive postoperative irradiation even when no clinical evide...

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