Methods to Increase the Percentage of Free Fetal DNA Recovered From the Maternal Circulation
Open Access
- 3 March 2004
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 291 (9) , 1114-1119
- https://doi.org/10.1001/jama.291.9.1114
Abstract
Prenatal diagnosis is useful for managing a pregnancy with an identified fetal abnormality and may allow for planning and coordinating care during delivery and the neonatal period.1 A variety of prenatal diagnostic tests are available but have limitations. Noninvasive tests such as maternal serum marker testing and ultrasound can be used to screen for the presence of chromosomal abnormalities but are not definitive.2-5 On the other hand, invasive diagnostic tests (eg, amniocentesis, chorionic villus sampling, percutaneous umbilical blood sampling) for fetal chromosomal abnormalities are highly reliable, but the procedure used for each test carries a risk for loss of pregnancy.6,7 Many patients who are candidates for these tests decline them because of the risk of pregnancy loss.Keywords
This publication has 9 references indexed in Scilit:
- Amniocentesis and chorionic villus sampling for prenatal diagnosisCochrane Database of Systematic Reviews, 2017
- Prenatal screening: invasive diagnostic approachesChild's Nervous System, 2003
- Accuracy of trisomy 18 screening using the second‐trimester triple testPrenatal Diagnosis, 2003
- Maternal serum cell-free fetal DNA levels are increased in cases of trisomy 13 but not trisomy 18Human Genetics, 2003
- Fetal DNA in maternal plasma: emerging clinical applicationsObstetrics & Gynecology, 2001
- Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal DiagnosisAmerican Journal of Human Genetics, 1998
- Presence of fetal DNA in maternal plasma and serumThe Lancet, 1997
- Advent of Maternal Serum Markers for Down Syndrome ScreeningObstetrical & Gynecological Survey, 1995
- Impact of Abnormal Second-Trimester Maternal Serum Single, Double, and Triple Screening on Patient Choices about Prenatal DiagnosisFetal Diagnosis and Therapy, 1995