SIMULTANEOUS MEASUREMENT OF SERUM 25-HYDROXYCHOLECALCIFEROL AND 25-HYDROXYERGOCALCIFEROL

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 57  (3) , 165-170
Abstract
A method for the selective measurement of serum 25-hydroxycholecalciferol (25-OHD3) and 25-hydroxyergocalciferol (25-OHD2) was developed. The 2 hydroxyergocalciferol were measured in a control group and in a group of ambulatory patients treated chronically with anticonvulsant drugs. In both groups the serum levels of 25-OHD3 and 25-OHD2 followed a log normal distribution. No significant difference could be elicited between the control and the treated groups for either hydroxysecosteroid. The dietary source of vitamin D in the environment is important. Since measurements of 25-hydroxycalciferol (25-OHD), 25-OHD2 and 25-OHD3, reasonably reflected the vitamin D repletion status in man, the selective measurement of 25-OHD2 and 25-OHD3 apparently could be a good index of the contribution of the dietary source (vitamin D2) and of the endogenous synthesis (vitamin D3) to the antirachitic activity of the secosteroids.].