Prevention of venous thrombosis in patients with intracranial disease by intermittent pneumatic compression of the calf

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Abstract
In a randomized study of 128 patients intermittent pneumatic compression of the calf was evaluated in the prevention of leg scan-detected venous thrombosis in intracranial disease. Pneumatic compression of the calf for 5 days reduced the rate of venous thrombosis from 12 of 63 control patients (19.1%) to 1 of 65 patients (1.5%) given prophylaxis (P = 0.00082). In patients who had craniotomy for brain tumor, subarachnoid hemorrhage, or subdural hematomas calf compression reduced the incidence of venous thrombosis from 9 of 49 control patients (18.4%) to 1 of 53 patients (1.9%) given prophylaxis (P = 0.0051). In patients who remained at risk after 5 days, the rate of venous thrombosis was no different in the control group than in the group that had received prophylaxis.

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