Increase of IgA-bearing Lymphocytes in Peripheral Blood from Patients with IgA Nephropathy
Open Access
- 1 February 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 71 (2) , 158-160
- https://doi.org/10.1093/ajcp/71.2.158
Abstract
Aberration of IgA-bearing B lymphocytes in patients with IgA nephropathy has been investigated. Twelve patients with IgA nephropathy demonstrated a marked increase of IgA-bearing lymphocytes in peripheral blood, while ten patients with chronic proliferative glomerulonephritis without mesangial deposition of IgA showed normal amounts of IgA-bearing lymphocytes. The increase of IgA-bearing lymphocytes reflected that of IgAproducing lymphocytes, since lymphocytes obtained from patients with IgA nephropathy restored a high percentage of IgAbearing cells in vitro after treatment with trypsin. Quantitation of IgA-bearing lymphocytes in peripheral blood is a useful method for screening of patients with IgA nephropathy.This publication has 0 references indexed in Scilit: