Platelet‐derived growth factor (PDGF) in type 1 diabetes mellitus

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Abstract
In 10 patients with type 1 diabetes mellitus, platelet-derived growth factor (PDGF) was assessed using an in vitro assay based on the stimulation of DNA synthesis in the 3T3 mouse fibroblast cell line. .beta.-Thromboglobulin (.beta.-TG) was used as an index for platelet .alpha.-granules content. Platelet .beta.-TG content and PDGF were markedly decreased in diabetic patients while plasma .beta.-TG was increased as compared with control subjects. In diabetic patients, a significant negative correlation was found between plasma .beta.-TG level and .beta.-TG total platelet content, associated with a significant positive correlation between platelet .beta.-TG content and PDGF. These results suggest that PDGF release might be increased in diabetic subjects. This may account in part for the cell proliferation observed in diabetic angiopathy.