MULTIPLE ANTIGEN FOR IMMUNIZATION AGAINST POLIOMYELITIS, DIPHTHERIA, PERTUSSIS, AND TETANUS

28 June 1958

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 167 (9) , 1103-1107
https://doi.org/10.1001/jama.1958.72990260001011

Abstract

The use of triple antigen (diphtheria, pertussis, and tetanus combined, or DPT) in pediatric practice is well established, and its efficacy has been reviewed and discussed by Edsall¹and Ipsen and Bowen.²With the accepted schedules of four-to-six-week intervals between inoculations, there has been good response to each of the three antigens in combination even when immunization is started at a very early age.³During 1956 the attack rates for paralytic poliomyelitis were highest in one-year-old children,⁴thereby also indicating the need for early poliomyelitis immunization. The widespread use of killed trivalent poliomyelitis vaccine in older children has been amply justified and the vaccine shown to evoke a response in infants.⁵On this basis poliomyelitis immunization of infants has been advocated⁶and the possibility of incorporation of the poliovirus antigens into DPT has aroused considerable interest. Response of infants to pertussis vaccine or DPT

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