Antagonism to the Diuretic Action of SR 720-22

Abstract
Ex 4877 blocked the diuretic effects of SR 720-22, a quinazolinone, indicating a broader spectrum of blocking action for Ex 4877 and a similarity in the mode of action between hydrochlorothiazide and SR 720-22. The results support the findings by Small and Cafruny (2) that Ex 4877 does not block the diuretic effects of furosemide.

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