The relationship between functional vasodilatation in adipose tissue and prostaglandin

Open Access
Publisher Website
Google Scholar
Abstract
. Earlier it had been found that during fat mobilization there was an increased blood flow in the adipose tissue and the tissue contained a vasodilator substance. . Extract of an activated fat pad contained 3 to 25 times as much activity as the contralateral resting fat pad. . The following findings suggest that the vasodilator substance is prostaglandin E2: It caused contractions of the guinea‐pig ileum which were not reduced by mepyramine, but were reduced by atropine. It caused a prolonged vasodilator response when injected close‐arterially to the epigastric fat pad. It was eluted from a silicic acid column by a solvent system which is known to elute prostaglandins of the E series but not those of the F series. Its indices of discrimination were similar to those of prostaglandin E's when assayed on three different pharmacological preparations. On thin‐layer chromatography it behaved more like prostaglandin E2 than E1. . Neither prostaglandin E1 nor prostaglandin E2 inhibited the release of free fatty acids from the rabbit epigastric fat pad by ACTH1–24. . It seems likely that prostaglandin E2 is responsible for the vasodilatation accompanying fat mobilization from adipose tissue.

This publication has 22 references indexed in Scilit: