Correlation of Lysyl Oxidase Activation with the p-Phenylenediamine Oxidase Activity (Ceruloplasmin) in Serum

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Abstract
A dietary deficiency in Cu decreases the lysyl oxidase activity in aortic tissue of growing chickens. The decrease was correlated with a lowering of serum Cu and ceruloplasmin (measured as p-phenylenediamine oxidase activity). Injections of CuSO4 restored enzyme function and brought serum Cu and ceruloplasmin levels back to normal. However, when the CuSO4 was given to chicks that had received 2 injections of estradiol-17.beta., a much stronger increase in lysyl oxidase in response to CuSO4 was observed. The enhanced response correlated with an enhanced increase in ceruloplasmin, linking the serum Cu protein with the restoration of lysyl oxidase activity.

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