Chronic Sulfur Dioxide Exposure in a Smelter II. Indices of Chest Disease

Abstract
Chronic SO2 exposure to rats, guinea pigs, monkeys and dogs is implicated as a causative factor of respiratory disease. Pulmonary function studies of smelter workers are presented. Symptoms of emphysema and chronic bronchitis are found, independent of tobacco consumption, with reduced forced vital capacity and flow expiratory volume in 1 s. Deficiency in the sulfite oxidase enzyme in some patients is suggested as a contributory factor.

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