Action of Certain Chemosterilants on Males of the Large Milkweed Bug1

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Abstract
Tretamine, topically applied in acetone solution, sterilized male Oncopellus fascialus (Dallas) with little effect on longevity, spermatogenesis, or mating. Tepa also was effective but more toxic; hempa was inert even at 1000 mg/kg; and the bis- and mono-aziridinyl analogues were intermediate both in toxicity and sterilant action. Metepa was a relatively nontoxic sterilant at 1000 mg/kg. A 60-day test at 30° with varying dosages of tretamine gave about 30% overall sterilization at 5 mg/kg, 50% at 10, and over 90% at 20. The effect was most intense during the first 15 days after treatment (100% sterility at both 10 and 20 mg/kg), then some males showed partial recovery of fertility. The ratio of apparently unfertilized eggs to fertilized eggs increased as tretamine dosage was increased, suggesting some reduction of spermatogenesis or mating as males grew older.

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