Habituation of the EEG arousal response in rats: Short- and long-term effects, frequency specificity, and wake–sleep transfer.

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Abstract
Presentation of auditory stimuli over interstimulus intervals (ISI) of several minutes to sleeping rats produced significant habituation of the EEG arousal response. The arousal response habituated to an asymptote after only 2 or 3 stimulus presentations. Little or no spontaneous recovery occurred between sessions separated by 24 or 72 h. The habituation produced by a single stimulus presentation was retained for at least 24 h, and orderly habituation was shown with a 24 h ISI. About 90% retention of habituation was shown 32 days following 10 stimulus presentations, and some degree of retention was shown for as long as 50 days. After habituation had reached a long-term asymptote, 600 stimulus presentations over 2-s ISI produced further response decrements, but these decrements recovered completely within a matter of minutes and responsiveness returned to the previously established long-term asymptote. Habituation was frequency-specific over both 24-h and 32-day intervals. Habituation produced stimulus presentations to awake animals transferred to the condition in which stimuli were presented to sleeping animals.

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