Activity of Acetylcholine System in Human Epileptogenic Focus

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Abstract
The activities of the components of the acetylcholine system were measured in samples of cerebral cortex from unanesthetized epileptic patients. The values obtained with epileptogenic focal tissue were compared with those from nonfocal tissue and with the probable values for normal human cortex predicted from a previous study of other animals. No signigicant differences between epileptogenic and nonepileptogenic or normal tissue were found in total acetylcholine content or in the rate of synthesis of free acetylcholine by slices incubated in media containing normal and high K concns. But epileptogenic tissue showed a tendency to have an elevated cholinesterace activity, and it showed a definite failure in its ability to produce bound acetylcholine.