Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development
Open Access
- 1 April 2000
- journal article
- review article
- Published by Springer Nature in Breast Cancer Research
- Vol. 2 (2) , 86-90
- https://doi.org/10.1186/bcr38
Abstract
STAT transcription factors were discovered 10 years ago as mediators of interferon-induced gene expression. They now form an important group, comprising seven members, that are activated by virtually every cytokine and growth factor. Their critical role in development and normal cell signaling has been largely determined through the analysis of transgenic mice lacking individual STAT genes. In addition, cell culture work has further delineated their importance in cellular transformation, apoptosis, differentiation and growth control. This review discusses the specific phenotypes of STAT-deficient animals with a focus on STAT5 and STAT3, as these two STAT molecules are required for normal breast development and involution, respectively, and may play an important role in breast carcinogenesis.Keywords
This publication has 72 references indexed in Scilit:
- The Myc oncoprotein: a critical evaluation of transactivation and target gene regulationOncogene, 1999
- Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cellsLeukemia, 1999
- bcl-2 protein expression is associated with a prognostically favourable phenotype in breast cancer irrespective of p53 immunostainingHistopathology, 1999
- Bcl-xLIs Expressed in Ovarian Carcinoma and Modulates Chemotherapy-Induced ApoptosisGynecologic Oncology, 1998
- Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 CellsPublished by Elsevier ,1996
- Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral DiseaseCell, 1996
- Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling PathwayCell, 1996
- Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesionsNature Medicine, 1995
- Inducible Gene Targeting in MiceScience, 1995
- Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic miceNature, 1994