Circadian pharmacokinetics of methotrexate
- 1 January 1989
- journal article
- conference paper
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 24 (6) , 397-399
- https://doi.org/10.1007/bf00257452
Abstract
Six patients with intermediate- and high-grade non-Hodgkin's lymphoma were treated with 400 mg/m2 i.v. methotrexate (MTX) at 0600 and 1800 hours. Despite evidence of circadian rhythms in renal function, the pharmacokinetics of total and free serum MTX showed no significant difference between these two times. The marked two-fold circadian variation in MTX pharmacokinetics previously reported in rats was not observed in these patients.Keywords
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