Terodiline in the Treatment of Children with Unstable Bladders

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Abstract
Summary— A double‐blind study of terodiline compared with placebo was performed in 58 children aged 6 to 14 years with urgency or urge incontinence. All had an unstable bladder at cystometry. A bladder regimen was emphasised during the study. Continence was improved according to micturition charting and a pad test in both groups. Terodiline at 25 mg/day, however, gave significantly better results than placebo. In patients with a subnormal bladder capacity ( 150 ml), a significant increase in capacity was recorded on cystometry during medication with terodiline but not with placebo.The improved continence seen in the placebo group was probably due to the non‐specific bladder training achieved by the child's increased awareness and adult involvement during treatment. The even better results attained in the terodiline group shows this drug to be a valuable adjunct to a bladder regimen in children with urge incontinence, particularly since no important adverse effects were noted during an 8‐week period.