Polyarthritis Induced in the Rat with Cell Walls from Several Bacteria and Two Streptomyces Species

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Abstract
Summary Various cell wall preparations from 9 different gram-positive strains were tested for AA induction in the Lewis rat by the lymph node injection method. A striking arthritogenic capability of the cell walls of M. bovis, BCG, and C. diphtheriae was noted to be essentially equivalent to that of M. tuberculosis. The cell walls from Streptomyces fradiae and lavendulae, L. plantarum, and S. aureus were less potent, and several other bacterial strains were not arthritogenic at all. However, when high molecular weight water soluble fractions were isolated from some of these strains, they too were often found to be arthritogenic, when administered in water-in-oil emulsions. We thank Barbara Vande Sande, Robin Yeaton, and Shigeki Nagao for skilled technical assistance.

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