Radiation inactivation of ricin occurs with transfer of destructive energy across a disulfide bridge.
- 1 August 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (16) , 5357-5359
- https://doi.org/10.1073/pnas.82.16.5357
Abstract
The ionizing radiation sensitivity of ricin, a disulfide-linked heterodimeric protein, was studied as a model to determine the ability of disulfide bonds to transmit destructive energy. The radiation-dependent loss of A chain enzymatic activity after irradiation of either intact ricin or ricin in which the interchain disulfide bond was disrupted gave target sizes corresponding to the molecular size of dimeric ricin or monomeric A chain, respectively. A disulfide bond can transmit destructive energy between protein subunits.This publication has 8 references indexed in Scilit:
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