Biliary Excretion of Iodipamide and Iodoxamate in Dogs with Hepatic Dysfunction Induced by Oral Administration of Dimethylnitrosamine
- 1 November 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Investigative Radiology
- Vol. 14 (6) , 502-507
- https://doi.org/10.1097/00004424-197911000-00010
Abstract
Iodipamide and iodoxamate were compared in equimolar clinical dosages in five cholecystectomized chronic bile fistula dogs in which hepatic dysfunction was produced by oral administration of a total dose of 480 and 960 μl dimethylnitrosamine (DMNA), respectively. After both DMNA dosages, the peak biliary excretion rate for iodoxamate was significantly higher than for iodipamide (p < 0.01). The peak bile iodine concentration was not significantly different for the two agents (480 μl DMNA: p > 0.1; 960 μl DMNA: p = 0.07). On the basis of this investigation, it is suggested that iodoxamate should not significantly improve the opacification of the biliary system in patients with hepatic dysfunction.Keywords
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