Investigation into the species-specific deacylation of penta-acetyl-gitoxin
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 14 (6) , 425-430
- https://doi.org/10.1007/bf00716384
Abstract
Penta-acetyl-gitoxin (PAG) shows species-specific deacylation to 16-acetyl-gitoxin (16-AG; I and III) or gitoxin (II and IV) by homogenates of liver and intestinal mucosa of man (I), rabbit (II), guinea-pig (III) and rat (IV), whereas it is degraded into tri- and tetra-acetates by homogenates of guinea-pig myocardium as well as by human blood and serum. The identity of the principal and chloroform-extractable metabolites in human urine after PAG administration with 16-AG has been demonstrated by mass spectrometry.This publication has 15 references indexed in Scilit:
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