An unbiased test for the bioequivalence problem
Open Access
- 1 December 1997
- journal article
- Published by Institute of Mathematical Statistics in The Annals of Statistics
- Vol. 25 (6) , 2345-2367
- https://doi.org/10.1214/aos/1030741076
Abstract
It is shown that the standard two one-sided tests procedure for bioequivalence is a biased test. Better tests exist. In this paper, an unbiased $\alpha$-level test and other tests which are uniformly more powerful than the two one-sided tests procedure are constructed. Its power can be noticeably larger than that of the $\alpha$-level two one-sided tests procedure.Keywords
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