The Changing Concepts of Guillain–Barré Syndrome

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Abstract
Guillain–Barré syndrome1,2 is a leading cause of acute paralysis. It occurs worldwide, in patients of all ages and both sexes. The weakness develops in a matter of days, sometimes with frightening rapidity and severity. Thirty percent of patients require treatment in critical care units, where ingenuity and resources are taxed to their maximum, and the stress on the patient and family is enormous. Nonetheless, modern management has reduced the mortality rate from 30 to 3 percent, and 75 percent of patients recover completely in 6 to 12 months.Guillain–Barré syndrome has traditionally been regarded as a poorly understood immune-mediated . . .