Gastrulation and Angiogenesis, Not Endothelial Specification, Is Sensitive to Partial Deficiency in Vascular Endothelial Growth Factor-A in Mice1
- 1 December 2003
- journal article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 69 (6) , 1852-1858
- https://doi.org/10.1095/biolreprod.103.019612
Abstract
Mouse embryogenesis is dose sensitive to vascular endothelial growth factor-A (VEGF-A), and mouse embryos partially deficient in VEGF-A die in utero bKeywords
This publication has 15 references indexed in Scilit:
- In vitro hematopoietic and endothelial potential of
flk-1
−/−
embryonic stem cells and embryosProceedings of the National Academy of Sciences, 1999
- The SCL gene specifies haemangioblast development from early mesodermThe EMBO Journal, 1998
- Hematopoietic Stem Cells in the Mouse Embryonic Yolk SacThe International Journal of Cell Cloning, 1996
- Heterozygous embryonic lethality induced by targeted inactivation of the VEGF geneNature, 1996
- Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleNature, 1996
- Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular developmentDevelopmental Dynamics, 1995
- Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumNature, 1995
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formationNature, 1995
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceNature, 1995
- Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.Proceedings of the National Academy of Sciences, 1993