Physiological disposition of a series of rifamycins in rat: A comparative study.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (9) , 894-901
- https://doi.org/10.7164/antibiotics.31.894
Abstract
Disposition of four C3-substituted piperazinyl rifamycins was studied in the rat following the i.v. administration of 5 mg/kg of [14C]-labelled antibiotics. Considerable quantitative differences in pharmacokinetics were shown in blood levels, tissue distributions and body clearances. Feces were largely the major route of elimination for the parent drug and metabolites. Liver compartmentalization, regulating the biliary excretion, may be the kinetic parameter affecting the pharmacokinetic behavior of rifamycins.This publication has 3 references indexed in Scilit:
- Studies of binding C3-substitute rifamycins to human and bovine serum albumin.The Journal of Antibiotics, 1977
- Biliary Excretion Rate of Semisynthetic Rifamycins in the RatChemotherapy, 1967
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951