PENICILLIN RESISTANCE IN NEISSERIA-GONORRHOEAE DUE TO BETA-LACTAMASE PRODUCTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 20  (79) , 39-46
Abstract
Two isolates of N. gonorrhoeae from 2 patients who did not respond to repeated treatment with penicillin contained an active .beta.-lactamase. This enzyme was not previously found in other gonococci isolated in the USA. Compared to other gonococci, these isolates had higher penicillin minimal inhibitory concentrations, and gave very small or no zones of inhibition in the disc agar diffusion test. The enzyme was demonstrated with 3 different rapid tests for .beta.-lactamase, by disc diffusion assay methods, and by GLC-mass spectrometry determination of penicilloic acid, the enzymatic end product from penicillin.

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