RESPONSE: Re: Population-Based, Case-Control Study of HER2 Genetic Polymorphism and Breast Cancer Risk
Open Access
- 4 April 2001
- journal article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 93 (7) , 558-559
- https://doi.org/10.1093/jnci/93.7.558
Abstract
We read with interest the letter by Drs. Baxter and Campbell regarding the association between HER2 genetic polymorphism and breast cancer risk. Drs. Baxter and Campbell found in a hospital-based, case–control study conducted among British women that genotype frequencies of the HER2 gene at codon 655 (Ile to Val) were similar between case patients with breast or ovarian cancer and control subjects. This finding was inconsistent with our finding in a population-based, case–control study conducted among Chinese women (1). In that study, we found that the Val/Val genotype was associated with an elevated risk of breast cancer, particularly among younger women (1).Keywords
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- Population Stratification in Epidemiologic Studies of Common Genetic Variants and Cancer: Quantification of BiasJNCI Journal of the National Cancer Institute, 2000
- Population-Based, Case-Control Study of HER2 Genetic Polymorphism and Breast Cancer RiskJNCI Journal of the National Cancer Institute, 2000
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