Susceptibilities to Ceftriaxone of Streptococcal Strains Associated with Infective Endocarditis

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Abstract
We determined the bactericidal activity of ceftriaxone on 20 streptococci isolated from patients with infective endocarditis and that of penicillin G on 5 strains. The MICs of ceftriaxone were .ltoreq. 2 .mu.g/ml and the MBCs were low for 5 nontolerant strains (.ltoreq. 2 .mu.g/ml) and high for 15 tolerant strains (.gtoreq. 16 .mu.g/ml). The maximal reduction of the viable bacterial counts after 24 h of exposure to antibiotic was achieved for a concentration of ceftriaxone of 4, 32 and 256 .mu.g/ml, respectively for 5, 10 and 19 strains. The activity of penicillin G was similar.