SOMATOSTATIN-INDUCED CHOLESTASIS CAN BE INDEPENDENT OF PORTAL BLOOD-FLOW

  • 1 January 1983
    • journal article
    • research article
    • Vol. 93  (5) , 649-652
Abstract
Short-term experiments were performed on adult mongrel dogs (15-25 kg) anesthetized with sodium pentobarbital. The operative procedure included cholecystectomy, side-to-side mesocaval shunt with ligation of the portal vein and cannulation of the common bile duct. I.v. sodium taurocholate (500 mg/h) was administered to prevent depletion of bile salts. Somatostatin (125 .mu.g over 30 min) was given to 6 dogs after 2 h of bile salt infusion, while 6 additional dogs received saline to serve as control. Bile flow decreased significantly during administration of somatostatin (206 .+-. 28 to 150 .+-. 21 .mu.l kg-1 15 min-1, P < 0.001) and was unchanged during administration of saline (216 .+-. 45 to 216 .+-. 46 .mu.l kg-1 15 min-1). This decrease persisted for 1/2 h after cessation of the somatostatin infusion. Bile salt outputs were similar for both groups throughout the experiment. Somatostatin-induced cholestasis can be independent of portal blood flow.

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