A STUDY OF SPONTANEOUS ACTIVITY IN THE EXCISED UTERUS OF THE RAT WITH PARTICULAR REFERENCE TO THE RÔLE OF THE OVARY AND INHERENT CHARACTERISTICS OF UTERINE MUSCLE

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Abstract
By a new method previously described the spontaneous activity of excised uteri of the very young (up to 21 days)., older but sexually immature, mature, old (menopause), and ovariectomized rats was determined and compared. A close relationship exists between all but the potentially active and the very young. The variations in activity observed are ascribed to 3 forces: (1) the spontaneity of uterine muscle in the absence of a specific or humoral influence as in the very young; (2) the ovarian influence direct, as in the sexually active; (3) extraovarian influence (possibly anterior pituitary) as in the ovariectomized, menopause, and those approaching sexual maturity. Uteri of these series exhibited no definite irritability to various doses (up to 50 rat units per horn) of theelin.

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