Chromosomal localization of human and rat Aα, Bβ, and γ fibrinogen genes by in situ hybridization
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 42 (1-2) , 36-41
- https://doi.org/10.1159/000132248
Abstract
In situ hybridization of radiolabeled fibrinogen cDNAs to human and rat metaphase chromosomes has shown that the genes encoding the Aα, Bβ, and γ fibrinogen subunits are syntenic in both species. Our data localize the human fibrinogen gene cluster to band q31 on chromosome 4, thereby confirming and extending previous map assignments of these genes in man. We have also assigned these genes to the q31→q34 region of rat chromosome 2. This is the first map assignment of these genes in the rat and also the first report to clearly establish linkage of the Bβ subunit gene to the Aα and γ genes in this species.Keywords
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