The Nature of the Subjective Reactions Evoked in Women by Progesterone with Special Reference to the Problem of Premenstrual Tension1

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Abstract
By using progesterone it was possible in the first part of the cycle to produce in one woman a condition simulating premenstrual tension and in others reactions similar to those encountered in the premenstruum. The subjective reactions elicited were not necssarily associated with disturbances of the menstrual rhythm and vice versa. Not all women were affected in the same way by progesterone, nor was the extent of the reaction dependent on dosage. The appreciation of the existence of individual sensitivity to hormones is of the utmost importance in determining treatment of menstrual disturbances and in the prognostication of the tendency towards disease in so-called normal women.

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