The pathogenesis of infection with Trypanosoma vivax in goats and cattle

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Abstract
The pathology of T. vivax (stock Y-486) in East African goats (Galla .times. Masai) and Friesian cattle was studied sequentially. In both goats and cattle parasitemia was detectable 6-7 days after inoculation with 1 .times. 105 trypanosomes. The goats were more susceptible than cattle as indicated by higher parasitemias, more severe anemia and death in 25% of the goats. The major pathological changes occurred in the lymph nodes, spleen, eyes, pituitary gland, testicles and heart. There was marked, generalized lymph node enlargement associated with an increase in the number and size of lymphocytic follicles accompanied by germinal center formation. The medullary cords of the lymph nodes were distended and distorted by the high population of plasma cells. Similar changes were noted in the spleen. There was no evidence for extramedullary erythropoiesis in both organs. Inflammatory changes were noted in the eyes, pituitary glands, testicles and heart.