Synthesis of Di- And Tri-Substituted Adenosine Derivatives and Their Affinities at Human Adenosine Receptor Subtypes
- 1 November 1999
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 18 (11-12) , 2511-2520
- https://doi.org/10.1080/07328319908044623
Abstract
The synthesis of 2-(hex-l-ynyl)adenosine derivatives substituted at the N6- and/or 5′-position was carried out on the basis that 2-(hex-l-ynyl)adenosine-5′-N-ethyluronamide (HENECA, 2) showed good affinity and different degree of selectivity for rat adenosine receptors. All new compounds were tested in radioligand binding and adenylyl cyclase assays with recently cloned human A1, A2A, A2B, and A3 adenosine receptors.Keywords
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