The effect of three injectable drugs and a combination of two of them was compared in birds. The agents were ketamine hydrochloride, xylazine hydrochloride and the steroid mixture alphaxalone-alphadolone. Ketamine and xylazine were used in combination. One hundred and fifty-four species, all maintained by major zoos in the United Kingdom, were involved in the study. The results indicate that the drugs used produced more widely differing effects in the range of species studied than have previously been reported.