Monoclonal Antibodies Against Flagllar Antigen ofSalmonella typhi

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Abstract
Two hybrid cell clones secreting monoclonal antibodies against flagellar antigen isolated from Salmonella typhi, were produced and characterized. The antibodies bound specifically to the flagellar strain of S.typhi and did not show any reactivity with aflagellar S.typhi or with flagellar strains of S.dublin, S.paratyphi A, S.paratyphi B, S.typhimurium, E.coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. The antibodies recognized a determinant present on a group of proteins migrating between 45 Kd and 60 Kd. These monoclonal antibodies would be useful reagents for clinical and epidemiological studies.