Abnormalities of the Left Temporal Lobe in Schizophrenia

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Abstract
Shenton et al. (Aug. 27 issue)1 report a reduction in limbic-tissue volume in their sample of patients with schizophrenia, but they found neither reduced global tissue nor enlarged ventricles. Using automated segmentation, others have demonstrated widespread deficits of brain-tissue volume in schizophrenia,2 and enlarged ventricles are commonly reported.3 Thus, the pattern of results of Shenton et al. differs from much of the literature. Their failure to demonstrate reduced global brain tissue and enlarged ventricles in schizophrenia may be due to measurement insensitivity, inadequate sample size, or nonrepresentative samples (patients or controls).