Failure of Conventional Doses of 1α,25-Dihydroxycholecalciferol to Correct Hypocalcemia in a Girl with Idiopathic Hypoparathyroidism

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Abstract
The candida endocrinopathy syndrome is characterized by chronic mucocutaneous candidiasis, endocrine-organ failure, usually of the parathyroid or adrenal glands, autoantibody formation against various endocrine glands and abnormalities of cell-mediated immunity.1 2 3 Hypoparathyroidism is the most frequent endocrinologic complication.4 The chronic hypocalcemia found cannot be treated with oral calcium since intestinal absorption of calcium in these patients is markedly reduced.5 Oral vitamin D, at a dose of 1.25 to 2.5 mg per day, is the mainstay of therapy,6 but even larger amounts may be required to maintain normal serum calcium concentrations. Patients "resistant" to therapy with vitamin D3, dihydrotachysterol and . . .