The effect of placebo and 'aggro' on the weal and flare response to histamine

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Abstract
No change in the weal and flare response to histamine was found after placebo and aggro, the former given double-blind, the latter in a blind study of 20 human subjects. Placebo and aggro actions may involve mechanisms other than the final response to mediators of inflammation. The weal and flare response to intradermal histamine is a reproducible and measurable vascular phenomenon. It was used to study the ameliorating action of placebos and to see whether the converse or aggro effect could be elicited.

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