The Effect of Fluoride Administration on Fluoride Deposition in Tissues and on Serum Cholesterol in the Rat

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Abstract
The effect of fluoride administration in the rat on the serum cholesterol level was studied. Doses of 0.5, 1.0, or 2.0 mg of fluoride daily by stomach tube over an experimental time of 4 to 8 weeks did not result in an increase of serum cholesterol. A level of 30 p.p.m. of fluoride provided in the drinking water over a period of 4 months similarly did not increase the normal serum cholesterol level of rats. Fluoride doses as high as 2.0 mg daily in rats receiving a semi-purified 15% fat diet, which is reported to enhance the toxicity of fluoride, were not found to increase the serum cholesterol level. The femora of rats receiving 15% cottonseed oil contained more fluoride than similar rats not receiving the added dietary fat, but whole carcass analysis did not confirm this observation. The hearts from animals receiving the 15% fat diet were shown to contain more fluoride than similar rats receiving no added dietary fat, while fluoride analysis of the kidneys did not show an increased fluoride retention in the animals receiving the semi-purified 15% fat diet.