Risk of stroke associated with abciximab among patients undergoing percutaneous coronary intervention.
Open Access
- 4 July 2001
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 286 (1) , 78-82
- https://doi.org/10.1001/jama.286.1.78
Abstract
Intravenous platelet glycoprotein (GP) IIb/IIIa receptor inhibitors effectively reduce thrombotic complications in patients undergoing percutaneous coronary intervention (PCI).1-6 In randomized studies, treatment with abciximab (a monoclonal antibody Fab fragment directed against the platelet GP IIb/IIIa receptor7) resulted in an approximate 50% reduction in the composite of death or myocardial infarction at 30 days.1-4 However, inhibition of platelet aggregation by GP IIb/IIIa receptor blockers such as abciximab increases the risk of bleeding complications, particularly when these agents are combined with conventional doses of heparin.1-8Keywords
This publication has 11 references indexed in Scilit:
- Effects of Stroke on Medical Resource Use and Costs in Acute Myocardial InfarctionCirculation, 1999
- Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction: a quantitative reviewJAMA, 1997
- A Randomized Comparison of Antiplatelet and Anticoagulant Therapy after the Placement of Coronary-Artery StentsNew England Journal of Medicine, 1996
- A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery DiseaseNew England Journal of Medicine, 1994
- A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery DiseaseNew England Journal of Medicine, 1994
- Individual risk assessment for intracranial haemorrhage during thrombolytic therapyThe Lancet, 1993
- A Comparison of Immediate Coronary Angioplasty with Intravenous Streptokinase in Acute Myocardial InfarctionNew England Journal of Medicine, 1993
- A Comparison of Immediate Angioplasty with Thrombolytic Therapy for Acute Myocardial InfarctionNew England Journal of Medicine, 1993
- Intracranial hemorrhage in association with thrombolytic therapy: Incidence and clinical predictive factorsJournal of the American College of Cardiology, 1992
- Percutaneous transluminal coronary angioplasty: report of complications from the National Heart, Lung, and Blood Institute PTCA Registry.Circulation, 1983