A RELATIONSHIP BETWEEN VITAMIN A METABOLISM AND CORTISONE

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Abstract
Administration of large doses of cortisone to normal or adrenalectomized rats on a stock or vitamin A free diet results in a rapid loss of vitamin A from their livers and the kidneys. Data suggest that the depletion of vitamin A in the liver as a result of inanition may be mediated through the adrenal gland. When vitamin A is supplied, adequate deposition occurs in the kidneys and livers of cortisone treated rats. It is suggested that the accumulation of carotene in the livers of rats treated with cortisone is a result of impaired conversion of beta-carotene into vitamin A. Adrenalectomy had no effect upon the conversion of beta-carotene into vitamin A or the deposition of the vitamin in the liver or kidney.

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