CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms
Open Access
- 1 June 2007
- journal article
- Published by American Society of Hematology in Blood
- Vol. 109 (11) , 4995-5001
- https://doi.org/10.1182/blood-2006-07-038703
Abstract
Overexpression of CKS1B, a gene mapping within a minimally amplified region between 153 to 154 Mb of chromosome 1q21, is linked to a poor prognosis iKeywords
This publication has 36 references indexed in Scilit:
- A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1Blood, 2006
- The molecular classification of multiple myelomaBlood, 2006
- Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantationBlood, 2006
- RNA Silencing of Cks1 Induced G2/M Arrest and Apoptosis in Human Lung Cancer CellsIUBMB Life, 2005
- Cyclin D dysregulation: an early and unifying pathogenic event in multiple myelomaBlood, 2005
- A Kinase-Independent Function of Cks1 and Cdk1 in Regulation of TranscriptionMolecular Cell, 2005
- Role of Cks1 Overexpression in Oral Squamous Cell CarcinomasThe American Journal of Pathology, 2004
- Genomic instability in multiple myeloma: Evidence for jumping segmental duplications of chromosome arm 1qGenes, Chromosomes and Cancer, 2004
- CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma CellsImmunity, 2002
- Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosisLeukemia, 2002