C1 AND HUMAN PLATELETS .2. DETECTION BY IMMUNOLOGICAL METHODS AND ROLE
- 1 January 1976
- journal article
- research article
- Vol. 30 (4) , 459-465
Abstract
A C1 [the 1st complement component] hemolytic activity was previously shown to be associated with platelets. The presence of C1 on human gel filtered platelets is confirmed by Ouchterlony analysis and platelet aggregation induced by anti-C1q [q fragment of C1] antisera. After cleavage of C1 by EDTA, platelet aggregation induced by aggregated IgG [immunoglobulin G] was decreased and was restored by the addition of C1. The possible role of C1 in human platelet aggregation induced by aggregated Ig or immune complexes is discussed.This publication has 18 references indexed in Scilit:
- Studies of the mechanisms of the human platelet release reaction induced by immunologic stimuli. I. Complement-dependent and complement-independent reactions.1974
- Release of Serotonin from Human Platelets Induced by Aggregated Immunoglobulins of Different Classes and SubclassesJournal of Clinical Investigation, 1973
- Platelet aggregation by large molecules.1973
- Evidence for C1 on Human PlateletsPathophysiology of Haemostasis and Thrombosis, 1973
- The effects of immune complexes on blood platelets and their relationship to complement activationImmunochemistry, 1972
- The effects of aggregated immunoglobulins on human blood platelets in relation to their complement-fixing abilities. I. Studies of immunoglobulins of different types.1972
- Aggregation of human gel-filtered platelets. Requirement of apyrase and proteins.1972
- Immunologic mechanisms of platelet damage.1972
- Qualitative description of factors involved in the retraction and lysis of dilute whole blood clots and in the aggregation and retraction of plateletsJournal of Clinical Investigation, 1970
- CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIESThe Journal of Experimental Medicine, 1963