Platelet Dysfunction Associated With Clozapine Therapy
- 1 October 1993
- journal article
- case report
- Published by Southern Medical Association in Southern Medical Journal
- Vol. 86 (10) , 1170-1172
- https://doi.org/10.1097/00007611-199310000-00021
Abstract
Clozapine, an atypical antipsychotic agent used in cases of treatment-resistant schizophrenia, is known for its relative absence of extrapyramidal side effects and its potential hazardous effect on white blood cell function. We have described a case of clozapine-associated epistaxis and reduction of the platelet count. Discontinuance of clozapine therapy resulted in cessation of epistaxis followed by normalization of the platelet count. We suggest routine monitoring of platelet count and function in patients treated with clozapine.Keywords
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